C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 39/102 (2006.01) A61P 27/16 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) C12N 1/20 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2520386
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110kDaNTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infecting, and treating and preventing NTHi related disorders are also contemplated.
La présente invention concerne une mutation à l'intérieur de l'opéron sap d'un clone avirulent d'une souche non classifiable en type de hémophilus influenzae (NTHi). Cette invention concerne aussi les gènes d'opéron sap et les polypeptides codés par ces séquences polynucléotidiques. Cette invention concerne aussi une nouvelle protéine de membrane externe 110kDaNTH et le polynucléotide codant pour cette protéine. Cette invention concerne enfin des techniques de recherche de NTHi infectant et des techniques de traitement et de prévention des troubles liés à NTHi.
Bakaletz Lauren O.
Munson Robert S. Jr.
Children's Hospital Inc.
Nationwide Children's Hospital Inc.
Smart & Biggar
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