Nootropic agent

Details Nootropic agent Nootropic agent

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/4439 (2006.01) C07D 207/27 (2006.01) C07D 207/273 (2006.01)

Patent

CA 2301782

A drug which improves cerebral neurotransmission based on interaction of long-term activation of a protein kinase C pathway and long-term activation of presynaptic nicotinic acetylcholine (nACh) receptors, and on an accompanying increase in the amount of released glutamate, which activates cerebral neurotransmission over a prolonged period. The substances of the present invention serve as excellent nootropic. They are particularly useful for the therapy of dementia caused by hydrocephalus, or by subdural hemorrhage.

L'invention concerne un produit pharmaceutique qui, par une interaction entre l'activation prolongée d'une voie d'activation de protéine kinase C et celle d'un récepteur de l'acétylcholine nicotinique (nAchR) présynaptique, permet d'accroître la sécrétion d'acide glutamique et d'activer la neurotransmission du cerveau pour une longue durée. Le produit pharmaceutique peut être utilisé comme excellent agent nootrope. En particulier, il est utile en tant qu'agent thérapeutique contre la démence dérivée de l'hydrocéphalie et d'un hématome sous-dural chronique.

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