Nootropic imidazolidinomes

Details Nootropic imidazolidinomes Nootropic imidazolidinomes

C - Chemistry, Metallurgy

07

K

530/5.04, 260/31

C07K 5/00 (2006.01) C07D 233/32 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1273450

A B S T R A C T CHEMICAL COMPOUNDS Compounds of Structure (1): Image (1) in which R1 is H, C1-5alkyl (straight or branched), or phenyl; W is a bond, -NHCHR6CO or -NHCHR6CONHCHR7CO-, where R6 and R7, which can be the same or different are H or C1-5alkyl (straight or branched); R2 is H, C1-5alkyl (straight or branched), aryl or a benzyl group optionally substituted by C1-5 alkyl (straight or branched), C1-4 alkoxy (straight or branched) or hydroxy; R3 and R4, which can be the same or different, are H, C1-5alkyl (straight or branched) or phenyl, or R3 and R4 can together form a 1,4-butylene or 1,5-pentylene group; R5 is H or -CHR8CONR9R10, where R8,R9 and R10, which can be the same or different, are H or C1-5alkyl (straight or branched); R11 and R12, which can be the same or different, are H, C1-5alkyl (straight or branched), or acyl or together with the nitrogen atom shown form a 2-oxo-pyrrolidino group optionally substituted in the 4-position by a hydroxy or C1-5 (straight or branched) alkoxy group, or a 5-oxo-1-imidazolidine group optionally substituted at the 2- position by one or two C1-5 alkyl groups or a 1,4-butylene or 1,5-pentylene group, or optionally substituted at the 4-position by C1-5 alkyl, or a pharmaceutically acceptable salt thereof, processes and intermediates for making them, pharmaceutical compositions containing them and their use as nootropic agents.

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