Nor-statine and nor-cyclostatine polypeptides in the...

Details Nor-statine and nor-cyclostatine polypeptides in the... Nor-statine and nor-cyclostatine polypeptides in the...

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2050049

64680-610 Abstract of the Disclosure A pharmaceutical composition for treating glaucoma or ocular hypertension is disclosed. The composition contains a nor-statine or nor-cyclostatine polypeptide of the formula: Image or Image II (wherein Z is R1-(Y)m-(A)p [in which R1 is alkyl, alkoxy, (substituted)amino, Y is CO, P(O)(OCH3) or SO2; A is N(CH3), NH or O, m and n are each 0 or l]; M is (substituted)phenyl, naphthyl, thienyl or benzyl; Q is methyl or halogen; R2 is (substituted)alkyl; W is substituted methylene; Z1 is CH2OH or R-U-T [in which R is CO, U is O, NH, NCH3, CH2 or a bond, and T is H, (substituted)alkyl, cycloalkyl, phenyl, or substituted amino]; L is CH or N; R5 is imidazol-4-ylmethyl or alkyl; and R6 is alkoxy or alkylamino).

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