Norepinephrine reuptake inhibitors and methods of using the...

A - Human Necessities – 61 – K

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A61K 31/5375 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2643231

Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition wherein inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions may comprise a compound having a pharmacological selectivity of serotonin (K i)/norepinephrine (K i) of at least about 5000. A preferred embodiment of a composition according to the invention comprises racemic reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.

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