Norethindrone sustained release formulations and methods...

Details Norethindrone sustained release formulations and methods... Norethindrone sustained release formulations and methods...

A - Human Necessities

61

K

A61K 31/56 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2483834

Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.

L'invention concerne des formulations de noréthindrone à libération prolongée. Dans un aspect, la formulation peut être une formulation transdermique contenant de la noréthindrone et de l'acétate de noréthindrone. Dans un autre aspect, la formulation peut contenir également un activateur de pénétration. Il s'avère que la coadministration de noréthindrone et d'acétate de noréthindrone présente divers avantages, elle permet notamment d'atteindre des taux sériques maximaux de noréthindrone sensiblement en 24 heures après le début de l'administration.

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