A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4355 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2736773
Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of viruses and other microbes within mammalian and other cells by inhibiting the cytoplasmic transport mechanisms within the cells. The compositions described herein include an effective amount of the noscapine analogues described herein, along with a pharmaceutically acceptable carrier or excipient. The compositions can also include one or more additional antimicrobial compounds.
La présente invention concerne des compositions et des procédés de traitement ou de prévention de maladies infectieuses, et d'inhibition de la capacité des microbes à voyager dans les cellules de mammifères, et d'inhibition de la réplication microbienne. Les compositions comprennent divers analogues de la noscapine, qui sont capables de bloquer le mouvement de virus et d'autres microbes dans des cellules de mammifères et d'autres cellules en inhibant les mécanismes de transfert cytoplasmique à l'intérieur des cellules. Les compositions décrites ici comprennent une quantité efficace des analogues de la noscapine décrits ici, en association avec un transporteur ou un excipient pharmaceutiquement acceptable. Les compositions peuvent également comprendre un ou plusieurs composés antimicrobiens supplémentaires.
Acuff Cory
Kalman Daniel
Emory University
Ridout & Maybee Llp
LandOfFree
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