Notch mutations leading to increased receptor signaling

Details Notch mutations leading to increased receptor signaling Notch mutations leading to increased receptor signaling

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/55 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2575552

The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increased receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.

L'invention concerne l'identification de régions situées à l'intérieur du récepteur NOTCH-1 qui, lorsqu'il mute, conduit à une signalisation dudit récepteur accrue. Les mutations sont associées à une croissance cellulaire incontrôlée, cette croissance pouvant être arrêtée au moyen d'agents qui interfèrent avec l'activité de NOTCH-1, tels que des inhibiteurs de la gamma-secrétase. On peut utiliser des dosages relatifs aux mutations de NOTCH-1 pour effectuer un diagnostic ou comme partie d'un schéma posologique de traitement de patients souffrant d'un cancer.

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