C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2729602
Means and methods for the diagnosis, characterization, prognosis and treatment of cancer, specifically targeting cancer stem cells are disclosed Provided is an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth, and a method of treating cancer comprising administering said antibody to a subject.
L'invention concerne des compositions et des procédés permettant de caractériser, de diagnostiquer et de traiter le cancer, et en particulier des moyens et des procédés pour le diagnostic, la caractérisation, le pronostic et le traitement du cancer et le ciblage spécifique de cellules souches du cancer. On décrit un anticorps se liant spécifiquement à une zone proximale de membrane de liaison hors ligand du domaine extracellulaire d'un récepteur Notch humain et inhibe la croissance tumorale. On décrit en outre un procédé de traitement du cancer qui consiste à administrer une quantité thérapeutiquement efficace d'anticorps se liant spécifiquement à la zone susmentionnée de récepteur Notch humain et inhibe la croissance tumorale.
Axelrod Fumiko Takada
Bruhns Maureen Fitch
Gurney Austin L.
Hoey Timothy Charles
Mbm Intellectual Property Law Llp
Oncomed Pharmaceuticals Inc.
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