Novel 1,1-bis(heteroazolyl)alkane derivatives and their use...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/22 (2006.01) A61K 31/41 (2006.01) A61K 31/427 (2006.01) A61K 31/445 (2006.01) C07D 263/32 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 293/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 421/06 (2006.01)

Patent

CA 2190128

The present invention relates to novel heterocyclic compounds having general formula (1), wherein: X1 and X2 are independently O, S or Se; Y1 and Y2 are independently C or N with the proviso that at least one of Y1 and Y2 is N; Y3 and Y4 are independently C or N with the proviso that at least one of Y3 and Y4 is N; R1 and R2 each represent one or more groups independently selected from H, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl or CF3; and A is (a) or (b) geometrical and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof; having therapeutic activity, processes and intermediates for their preparation, pharmaceutical formulations containing said compounds and the medicinal use of said compounds.

La présente invention se rapporte à de nouveaux composés hétérocycliques de la formule générale (1), dans laquelle X¿1? et X¿2? représentent indépendamment O, S, ou Se; Y¿1? et Y¿2? représentent indépendamment C ou N, sachant qu'au moins l'un d'entre eux représente N; Y¿3? et Y¿4? représentent indépendamment C ou N, sachant qu'au moins l'un d'entre eux représente N; R¿1? et R¿2? représentent chacun un ou plusieurs groupes indépendamment choisis entre H, alkyle inférieur, alcoxy inférieur-alkyle inférieur, hydroxy-alkyle inférieur, acyloxy inférieur-alkyle inférieur ou CF¿3?; et A représente (a) ou (b). L'invention porte également sur leurs racémates et isomères géométriques et optiques, s'ils existent, et les solvates et sels d'addition d'acide pharmaceutiquement acceptables de ces composés, qui présentent une activité thérapeutique. L'invention se rapporte en outre à leur préparation, à des formulations pharmaceutiques les contenant, ainsi qu'à leur utilisation médicale.

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