C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4725 (2006.01) A61P 31/10 (2006.01) C07C 45/29 (2006.01) C07C 47/457 (2006.01) C07D 217/04 (2006.01) C07D 521/00 (2006.01) C07F 7/22 (2006.01)
Patent
CA 2405126
The invention concerns compounds of formula (I) wherein: p = 1 or 2; X, X¿1? and X¿2? represent N or CH=; R¿1?, R¿2?, R¿3?, R¿4?, R¿5? and R¿6? represent a hydrogen atom, a halogen atom, alkyl, O-alkyl, S-(O)¿n?alkyl, alkenyl, O-alkenyl, S-(O)¿n?alkenyl, alkynyl, O-alkynyl, S-(O)¿n?alkynyl; n = 0, 1 or 2, or NO¿2?, NH¿2? or C=N or R¿1?, R¿2?, R¿3? or R¿5?, R¿6? form a cycle, or R¿4?A can be cycloalkyl, heterocycle, aryl, O-aryl or oxygenated or nitrogenated chain; R¿7? represents H, OH, SO¿3?H or OPO(OH)¿2?; A and B = hydrogen or oxygenated or nitrogenated chain; C and D = hydrogen, halogen or alkyl or together form with the carbons bearing them a cycle. The compounds of formula (I) have antifungal properties.
L'invention a pour objet les composés de formule (I): dans lesquels p = 1 ou 2, X, X1 et X2 représentent N ou CH=, R1, R2, R3, R4A, R5 et R6 représentent un atome d'hydrogène, d'halogène, alkyle, O-alkyle, S-(O)nalkyle, alkényle, O- alkényle, S-(O)n alkényle, alkynyle, O-alkynyle, S-(O)nalkynyle, n = 0, 1 ou 2, ou NO2, NH2 ou C.ident.N ou R1, R2, R3 ou R5, R6 forment un cycle, ou R4A peut être cycloalkyle, hétérocycle, aryle, O-aryle ou chaîne oxygénée ou azotée, R7 représente H, OH, SO3H ou OPO(OH)2, A et B = hydrogène ou chaîne oxygénée ou azotée; C et D = hydrogène, halogène ou alkyle ou forment ensemble avec les carbones qui les portent un cycle. Les composés de formule (I) présentent des propriétés antifongiques.
Babin Didier
Benedetti Yannick
Chatreaux Fabienne
Weston John Bernard
Aventis Pharma S.a.
Robic
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