C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01)
Patent
CA 2476056
The invention concerns derivatives of formula (I), wherein R¿1? represents -OH, (C¿1?-C¿5?) alkoxy, carboxyl, (C¿2?-C¿6?) alkoxycarbonyl, -NR¿5?R¿6?, -NH-SO¿2?-Alk, -NH-SO¿2?-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CO¿2?-alk,-O-(CH¿2?)¿n?-cAlk, -O-Alk-COOR¿7?,-O-Alk-O-R¿8,?-O-Alk-OH, -O-Alk-C(NH¿2?):NOH, -O-Alk-NR¿5?R¿6?, -O-Alk-CN, -O-(CH¿2?)¿n?-Ph, -O-Alk-CO-NR¿5?R¿6?, -CO-NH-(CH¿2?)¿m?-COOR¿7?, -CO-NH-Alk; R2 represents H, (C¿1?-C¿5?) alkyl, (C¿1?-C¿5?) alkyl halide, (C¿3?-C¿6?) cycloalkyl or phenyl optionally substituted; A represents -CO-, -SO- or -SO¿2?-; R¿3? and R¿4? identical or different represent each H, (C¿1?-C¿5?) alcoxyl, amino, carboxy, (C¿2?-C¿6?) alkoxycarbonyl, -OH, nitro, hydroxyamino, -Alk-COOR¿7?, -NR¿5?R¿6?, -NH-Alk-COOR¿7?, -NH-COO-Alk, -N(R¿11?)-SO¿2?-Alk-NR¿9?R¿10?, -N(R¿11?)-SO¿2?-Alk,-N(R¿11?)-Alk-NR¿5?R¿6?, -N(R¿11?)-CO-Alk-NR¿9?R¿10?, -N(R¿11?)-CO-Alk, -N(R¿11?)-CO-CF¿3?, -NH-Alk-HetN, -O-Alk-NR¿9?R¿10?, -O-Alk-CO-NR¿5?R¿6?, -O-Alk-HetN, or R¿3 ?and R¿4? form together an unsaturated heterocycle of 5 to 6 members, optionally in the form of one of their pharmaceutically acceptable salts.
La présente invention concerne des dérivés de formule I : dans laquelle R1 représente -OH, alcoxy(C1-C5, carboxyl, alcoxycarbonyle (C2-C6), -NR5R6, -NH- SO2-Alk, -NH-SO2-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH- CO2-alk,-O-(CH2)n-cAlk, -O-Alk-COOR7,-O-Alk-O-R8,-O-Alk-OH, -O-Alk-C(NH2) :NOH, -O-Alk-NR5R6, -O-Alk-CN, -O-(CH2)n-Ph, -O-Alk-CO-NR5R6, -CO-NH-(CH2)m- COOR7, -CO-NH-Alk, R2 représente H, alkyle (C1-C5), halogenure d~alkyle (C1- C5), cycloalkyle (C3-C6) ou phényle éventuellement substitué, A représente -CO- , -SO- ou -SO2-, R3 et R4 identiques ou différents représentent chacun H, alcoxyl (C1-C5), amino, carboxyl, alcoxycarbonyle (C2-C6), -OH, nitro, hydroxyamino, -Alk-COOR7, -NR5R6, -NH-Alk-COOR7, -NH-COO-Alk, -N(R11)-SO2-Alk- NR9R10, -N(R11)-SO2-Alk,-N(R11)-Alk-NR5R6, -N(R11)-CO-Alk-NR9R10, -N(R11)-CO- Alk, -N(R11)-CO-CF3, -NH-Alk-HetN, -O-Alk-NR9R10, -O-Alk-CO-NR5R6, -O-Alk- HetN, ou R3 etR4 forment ensemble un hétérocycle insaturé de 5 à 6 chaînons, éventuellement sous la forme de l~un de leurs sels pharmaceutiques acceptables.
Badorc Alain
Bono Francoise
Bordes Marie-Francoise
Guillo Nathalie
Herbert Jean-Marc
Kirby Eades Gale Baker
Sanofi-Aventis
LandOfFree
Novel 1,2,3-substituted indolizine derivatives, inhibitors... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel 1,2,3-substituted indolizine derivatives, inhibitors..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel 1,2,3-substituted indolizine derivatives, inhibitors... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1928390