C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/08 (2006.01) A61K 31/433 (2006.01) A61P 3/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2466140
The present invention is directed to novel 1,2,4-thiadiazole derivatives of the formula (II) wherein R1, R2 and R4, are ring containing radicals, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders.
L'invention concerne de nouveaux dérivés de 1,2,4-thiadiazole représentés par la formule II, dans laquelle R?1¿, R?2¿ et R?4¿ représentent des radicaux contenant des noyaux, et qui constituent des agonistes ou des antagonistes du récepteur de la mélanocortine. Plus particulièrement, les composés de l'invention sont utiles pour traiter des affections métaboliques, dermatologiques et du système nerveux central.
Eisinger Magdalena
Fitzpatrick Louis J.
Lee Daniel H.
Pan Kevin
Plata-Salaman Carlos
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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