C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/08 (2006.01) A61K 31/433 (2006.01) A61P 3/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2466145
The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives of the formula (I); wherein R1, R2 and R4 are ring containing radicals, R3 is H, alkyl, alkenyl or alkynyl, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatement of metabolic, CNS and dermatological disorders.
L'invention concerne des dérivés 1,2,4-thiadiazol-2-ium de formule (I), dans laquelle R?1¿, R?2¿ et R?4¿ représentent des cycles contenant des groupes, R?3¿ représente un atome d'H, un groupe alkyle, alcényle ou alkynyle, utiles en tant qu'agonistes ou antagonistes du récepteur de mélanocortine. Les composés de l'invention sont plus particulièrement utiles pour le traitement de troubles métaboliques, du SNC et dermatologiques.
Eisinger Magdalena
Fitzpatrick Louis J.
Lee Daniel H.
Pan Kevin
Plata-Salaman Carlos
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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