C - Chemistry – Metallurgy – 09 – K
Patent
C - Chemistry, Metallurgy
09
K
C09K 11/06 (2006.01) C09K 11/02 (2006.01)
Patent
CA 2594846
A chemiluminescent assay method and compositions are described which use a haloalkoxy group-substituted dioxetane which is deprotected by a hydrolytic enzyme to undergo a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane compounds substituted on the dioxetane ring with a haloalkoxy group which can be triggered by a reagent to generate light are disclosed. Haloalkoxy group-substituted dioxetanes are useful for the detection of triggering agents including enzymes. The enzyme may be present alone or linked to a member of a specific binding pair in an immunoassay, DNA probe assay or other assay where the enzyme is bound to a reporter molecule.
Akhavan-Tafti Hashem
Arghavani Zahra
Eickholt Robert
Rashid Khaledur
Applera Corporation
Applied Biosystems Llc
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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