Novel 1,2-diphenyl-2-propen-1-one derivatives

Details Novel 1,2-diphenyl-2-propen-1-one derivatives Novel 1,2-diphenyl-2-propen-1-one derivatives

C - Chemistry, Metallurgy

07

C

C07C 225/16 (2006.01) A61K 31/137 (2006.01) A61P 27/06 (2006.01) C07C 215/30 (2006.01) C07C 233/17 (2006.01) C07C 233/22 (2006.01) C07C 233/31 (2006.01)

Patent

CA 2359470

Compounds represented by general formula (I) or salts thereof which cause a morphological change in trabecular cells to thereby lower intraocular pressure. In the formula, R1 represents H, lower alkyl, hydroxy, lower alkoxy or halogeno; R2, R3 and R4 represent each H or lower alkyl; and <u>---</u> represents a single or double bond, provided that when R3 and/or R4 are hydrogen, then the amino may be protected.

On décrit des composés représentés par la formule générale (I) ou des sels de ces derniers qui produisent un changement morphologique dans les cellules trabéculaires de manière à réduire ainsi la pression intra-oculaire. Dans la formule, R?1¿ représente H, alkyle inférieur, hydroxy, alcoxy inférieur ou halogéno; R?2¿, R?3¿ et R?4¿ représentent chacun H ou alkyle inférieur; et <u>---</u> représente une liaison simple ou double, à condition que lorsque R?3¿ et/ou R?4¿ représente(ent) hydrogène, l'élément amino puisse être protégé.

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