Novel [1,4]benzodiazepines as vasopressin v2 receptor...

Details Novel [1,4]benzodiazepines as vasopressin v2 receptor... Novel [1,4]benzodiazepines as vasopressin v2 receptor...

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/5513 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2585449

The invention is directed to novel [1,4]benzodiazepine compounds useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising [1,4]benzodiazepine compounds of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia,, stroke, thrombosis, or water retention are also disclosed.

Cette invention porte sur de nouveaux composés [1,4]benzodiazépiniques. Ces composés, qui conviennent comme antagonistes de récepteurs de la vasopressine, s'adressent au traitement d'états impliquant une résistance vasculaire accrue accompagnée d'insuffisance cardiaque. L'invention concerne également des compositions pharmaceutiques intégrant les composés [1,4]benzodiazépiniques de l'invention et des applications permettant de traiter des états tels que l'hypertension, l'insuffisance cardiaque congestive, l'insuffisance cardiaque, les vasospasmes coronariens, l'ischémie cardiaque, la cirrhose hépatique, les vasospasmes rénaux, l'insuffisance rénale, les ischémies et oedèmes cérébraux, l'ictus cérébral, la thrombose ou la rétention d'eau.

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