C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 243/00 (2006.01)
Patent
CA 2496585
This invention relates to novel 1,4-diazabicycloalkane derivatives of formula (I): any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically-acceptable addition salt thereof, or an N-oxide thereof, and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Cette invention concerne des dérivés de 1,4-diazabicycloalkane représentés par la formule (I), l'un quelconque de ses énantiomères ou un quelconque mélange de ses énantiomères, ou bien un sel d'addition pharmaceutiquement acceptable ou un oxyde d'azote de ces dérivés, et leur utilisation pour la préparation de compositions pharmaceutiques. Il apparaît que les composés de l'invention sont des ligands cholinergiques au niveau des récepteurs de l'acétylcholine nicotinique et des modulateurs des récepteurs et des transporteurs de la monoamine. De par leur profil pharmacologique, lesdits composés peuvent être utiles pour le traitement de maladies ou de troubles les plus divers en rapport avec: le système cholinergique ou le système nerveux central, le système nerveux périphérique, la contraction des muscles lisses, le système endocrinien, la neurodégénérescence, l'inflammation, la douleur et les symptômes de sevrage provoqués par l'arrêt de l'abus de substances chimiques.
Ahring Philip K.
Dyhring Joergensen Tino
Nielsen Elsebet Oestergaard
Olsen Gunnar M.
Peters Dan
Mccarthy Tetrault Llp
Neurosearch A/s
LandOfFree
Novel 1,4-diazabicycloalkane derivatives, their preparation... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel 1,4-diazabicycloalkane derivatives, their preparation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel 1,4-diazabicycloalkane derivatives, their preparation... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1625026