Novel 10-cyclohexenyl-phenyl...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 5/10 (2006.01) A61P 15/06 (2006.01)

Patent

CA 2443566

The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of dysfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

La présente invention concerne des composés de carboxamide tricyclique, ainsi que des procédés et des compositions pharmaceutiques utilisés pour traiter et/ou prévenir et/ou supprimer des troubles susceptibles d'être guéris ou soulagés par une activité antagoniste de l'ocytocine, y compris pour prévenir et/ou supprimer le travail avant terme, supprimer le travail à terme avant un accouchement par césarienne et pour traiter la dysménhorrée. Les composés de l'invention sont également utilisés pour augmenter les taux de fertilité, les taux de survie, pour synchroniser les chaleurs chez les animaux d'élevage, et ils peuvent être utilisés pour prévenir et traiter les dysfonctionnements du système à ocytocine dans le système nerveux central, y compris les troubles obsessionnels compulsifs (TOC) et les troubles neuropsychiatriques.

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