Novel 2,3-dihydro-4(1h)-pyridinone derivatives, method for...

C - Chemistry – Metallurgy – 07 – D

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C07D 409/04 (2006.01) A61K 31/44 (2006.01) C07D 211/86 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2503993

Compounds of formula (I), where: R¿1? = H, straight- or branched-chain arylalkyl (C¿1?-C¿6?), straight- or branched-chain alkyl (C¿1?-C¿6?), straight- or branched-chain acyl (C¿1?-C¿6?), straight- or branched-chain alkoxycarbonyl (C¿1?-C¿6?), straight- or branched-chain arylalkoxycarbonyl (C¿1?-C¿6?), or trifluoroacetyl, R¿2? = straight- or branched-chain alkyl (C¿1?-C¿6?), X = O, or NOR¿3?, R¿3 ?= H, straight- or branched-chain alkyl (C¿1?-C¿6?) optionally substituted by one or several different or similar groups, from hydroxy, amino (optionally substituted by one or two groups of straight- or branched-chain alkyl (C¿1?-C¿6?)) and straight- or branched-chain alkoxy (C¿1?-C¿6?) and Ar = aryl or heteroaryl, also the isomers and salts thereof with a pharmaceutically-acceptable acid and the use thereof as a cognitive memory aid and analgesic.

Composés de formule (I) : dans laquelle : R1 représente un atome d'hydrogène ou un groupement arylalkyle (C1-C6) linéaire ou ramifié, alkyle (C1-C6) linéaire ou ramifié, acyle (C1-C6) linéaire ou ramifié, alkoxycarbonyle (C1- C6) linéaire ou ramifié, arylalkoxycarbonyle (C1-C6) linéaire ou ramifié ou trifluoroacétyle, R2 représente un groupement alkyle (C1-C6) linéaire ou ramifié, X représente un atome d'oxygène, ou NOR3, R3 représente un atome d'hydrogène ou un groupement alkyle (C1-C6) linéaire ou ramifié éventuellement substitué par un ou plusieurs groupements, identiques ou différents, choisis parmi hydroxy, amino (éventuellement substitué par un ou deux groupements alkyle (C1-C6) linéaire ou ramifié) et alkoxy (C1-C6) linéaire ou ramifié, Ar représente un groupement aryle ou un groupement hétéroaryle, leurs isomères ainsi que leurs sels d'addition à un acide pharmaceutiquement acceptable et leur utilisation en tant que facilitateurs mnémocognitifs et antalgiques.

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