Novel 2,3 disubstituted-4(3h)-quinazolinones

Details Novel 2,3 disubstituted-4(3h)-quinazolinones Novel 2,3 disubstituted-4(3h)-quinazolinones

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/505 (2006.01) C07D 239/91 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01)

Patent

CA 2252907

Disclosed are novel compounds of the formula: (see formula I) (wherein R1 is optionally substituted phenyl or pyridyl; R2 is phenyl or 5- or 6-membered heteroaryl; and R3 is H, halo, CN, NO2, CF3, alkyl or alkoxy) which are .alpha.-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and are useful as medicine for treating neurodegenerative and CNS-trauma related conditions.

L'invention concerne de nouveaux composés de 4(3H)-quinazolinones disubstituées en position 2,3, qui ont la formule (I), leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiques et des méthodes de traitement des états neurodégénératifs ou liés à un traumatisme du S.N.C.

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