Novel 2,4-diaminothiazole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/42 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 3/00 (2006.01) A61P 25/28 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2455753

Novel 2,4-diaminothiazole derivatives of the general formula (I) which inhibit GSK-3 (glycogen synthase kinase-3), use of these compounds as medicaments, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful for the treatment of disorders, syndromes, diseases and conditions, wherein an inhibition of GSK-3 (glycogen synthase kinase-3) is beneficial, especially IGT (impaired glucose tolerance), type 1 diabetes, type 2 diabetes, obesity, Alzheimer's disease and bipolar disorder.

L'invention porte: sur de nouveaux dérivés de la 2,4-diaminothiazole de formule générale (I) inhibiteurs de la GSK-3 (glycogène synthase kinase-3), sur l'utilisation de ces composés comme médicaments; sur des préparations pharmaceutiques les contenant et sur des procédés de traitement utilisant lesdits composés et compositions. Lesdits composés peuvent servir à traiter des troubles, syndromes, maladies et états où l'inhibition de la GSK-3 (glycogène synthase kinase-3) est bénéfique, et spécialement: la diminution de la tolérance au glucose, le diabète de type 1, le diabète de type 2, l'obésité, la maladie d'Alzheimer et les troubles bipolaires.

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