Novel 2-heteroaryl substituted indoles 695

Details Novel 2-heteroaryl substituted indoles 695 Novel 2-heteroaryl substituted indoles 695

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2680055

The present invention relates to novel 2-heteroaryl substituted indole derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel 2-heteroaryl substituted indole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer?s disease therapeutic agents.

L'invention concerne de nouveaux dérivés d'indole à substitution 2-hétéroaryle, leurs précurseurs, et les utilisations thérapeutiques de tels composés, ayant la formule structurelle (Ia) : et leur sel pharmaceutiquement acceptable, leurs compositions, et leurs procédés d'utilisation. En outre, l'invention concerne de nouveaux dérivés d'indole à substitution 2-hétéroaryle, qui conviennent pour une imagerie de dépôts amyloïdes chez des patients vivants, leurs compositions, et leurs procédés d'utilisation et de fabrication. La présente invention concerne plus spécifiquement un procédé d'imagerie de dépôts amyloïdes dans un cerveau in vivo,pour permettre un diagnostic ante mortem de la maladie d'Alzheimer, tout comme une mesure de l'efficacité clinique d'agents thérapeutiques contre la maladie d'Alzheimer.

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