Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives

Details Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/54 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 3/06 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2355243

This invention provides novel 2-(N-cyanoimino)thiazolidin-4-one derivatives represented by formula I or a pharmaceutically acceptable salt or solvate thereof: Image wherein ring A represents a benzene ring, a condensed ring or a heterocyclic ring, each of which may be substituted by one or more substituents selected from a straight or branched C1 - C4 alkyl group, a haloalkyl group, a halogen atom or -OR5, R1 represents a single bond, an oxygen atom, a sulfur atom, a methyne group, a straight or branched C1 - C4 alkylene or alkenylene group optionally substituted by a phenyl group, R6-X, X-R6, X-R6-X, R6-X-R6, -C(=O)-NR7- or -NR7-C(=O)-, R2 and R3 are the same or different and each represents a hydrogen atom, a C1 - C4 alkyl group, -OR8 or a halogen atom, R4 represents a hydrogen atom or a C1 - C4 alkyl group, R5 represents a hydrogen atom or a C1 - C4 alkyl group, R6 represents a straight or branched C1 - C4 alkylene or alkenylene group, R7 represents a hydrogen atom or a C1 - C4 alkyl group, R8 represents a hydrogen atom, a C1 - C4 alkyl group or an aralkyl group, X represents an oxygen atom or a sulfur atom. They have excellent activities of lowering triglyceride and cholesterol levels, and are useful for preventing from and/or treating hyperlipidemia and related complications.

Cette invention se rapporte à de nouveaux dérivés de 2-(N-cyano-imino)thiazolidin-4-one, représentés par la formule générale (I), qui possèdent un excellent pouvoir d'abaissement du cholestérol et d'abaissement des triglycérides et qui sont utiles pour prévenir ou traiter l'hyperlipidémie et les maladies qui en résultent.

Affiliated with

Also associated with

Rating

Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1762288