Novel 2'-o-alkyl nucleosides and phosphoramidites processes...

Details Novel 2'-o-alkyl nucleosides and phosphoramidites processes... Novel 2'-o-alkyl nucleosides and phosphoramidites processes...

C - Chemistry, Metallurgy

12

P

C12P 19/40 (2006.01) A61K 31/70 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2140428

Novel 2'-O-alkyl guanosine compounds and analogs thereof are provided. Processes for the preparation of 2'-O-alkyl guanosine and analogs thereof are also provided. Processes for preparing 2'-O- alkylated guanosine, uridine, cytidine, and 2,6-di- aminopurine 3'-O-phosphoramidites are also provided. Methods for the use of oligonucleotides comprising 2'-O-alkyl guanosine are also provided.

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