Novel 2-saccharinylmethyl aryl carboxylates useful as...

C - Chemistry – Metallurgy – 07 – D

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C07D 275/06 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01) C07D 513/04 (2006.01) C07F 9/6541 (2006.01)

Patent

CA 2054653

26299-18 ABSTRACT OF THE DISCLOSURE Disclosed are novel 2-saccharinylmethylaryl carbonates of the formula: Image (wherein Ar is phenyl, naphthyl or anthryl or such a group substituted one to three substituents such as alkyl, alkoxy, amino, halogen, hydroxy etc.; R4 is such as hydrogen, halogen, alkyl, cyano, amino, alkoxy, alkoxy carbonyl or phenyl; and R5 is hydrogen or substituent such as halogen, cyano, nitro, amino, etc. or R5 is a 5- or 6-membered saturated ring fused to the saccharin), similar compounds of the formula: Image (wherein R4a is hydrogen, alkyl or phenyl; R6 is hydrogen or primary alkyl; or R4a and R6 together form spirocyclopropyl; R7 is hydrogen or alkoxy; and Ar is as defined above) and of the formula: 26299-18 Image (wherein A is methylene, ethylene or dimethylmethylene and Ar is as defined above), useful in the treatment of degenerative diseases.

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