Novel 3,4-diaryl thiophenes and analogs thereof having use...

Details Novel 3,4-diaryl thiophenes and analogs thereof having use... Novel 3,4-diaryl thiophenes and analogs thereof having use...

C - Chemistry, Metallurgy

07

D

C07D 333/04 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07C 319/14 (2006.01) C07D 207/32 (2006.01) C07D 307/34 (2006.01) C07D 307/38 (2006.01) C07D 307/58 (2006.01) C07D 333/16 (2006.01) C07D 333/18 (2006.01) C07D 333/28 (2006.01) C07D 333/38 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2152792

A class of 3,4-diaryl substitued thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions con- taining them and methods of using them to treat inflammation and Image (I) inflammation-related disorders. Compounds of particular interest are defined by formula (I), wherein Y is selected from O, S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycar- bonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted at a substi- tutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically- acceptable salt thereof.

L'invention se rapporte à une classe de thiophènes à substitution 3,4-diaryle, à des dérivés de de furane et pyrrole et leurs analogues, aux compositions pharmaceutiques les contenant et à leurs procédés d'utilisation permettant de traiter les maladies inflammatoires et maladies relatives aux inflammations. Des composés d'un intérêt particulier sont définis par la formule (I), dans laquelle Y est sélectionné parmi O, S et NR1; R1 est sélectionné parmi hybrido et alkyle inférieur; X représente un ou deux substituants sélectionnés parmi hybrido, halo, alcoxycarbonyle inférieur et carboxyle; R2 et R3 représentent indépendamment aryle ou hétéroaryle; et R2 et R3 sont éventuellement substitués au niveau d'une position substituable par un ou plusieurs radicaux sélectionnés parmi sulfamyle, alkylsulfonyle, halo, alcoxy inférieur et alkyle inférieur; ou un sel pharmaceutiquement accpetable de ceux-ci.

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