C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/34 (2006.01) A61K 31/18 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61P 19/00 (2006.01) C07C 311/16 (2006.01) C07C 317/24 (2006.01) C07D 207/30 (2006.01) C07D 213/55 (2006.01) C07D 333/18 (2006.01) C07D 333/26 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (
Patent
CA 2243199
A class of 3, 4-diary substituted thiophene, furan and pyrole derivatives and analogs thereof; pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (I), (see formula I) wherein Y is selected from O. S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituents selected from hydrido, halo, lower alkcoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl and wherein R2 and R3 are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, allcylsulfonyl, halo, lower alkcoxy and lower alkyl; or a pharmaceutically acceptable slat thereof.
Bertenshaw Stephen R.
Talley John J.
G.d. Searle & Co.
Mcfadden Fincham
Monsanto Company
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