C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/20 (2006.01) A61K 31/423 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2597781
The invention concerns novel products of formula (I), wherein: A1 and A2 represent CH or N; X represents Cra or N; Y represents CRb or N; R1, R2, R3 and R4 identical or different represent in particular hydrogen, halogen, cyano, nitro, trifluoromethyl, OR5, SR5, NR5R6, C(O)R5, C(O)OR5, C(O) NR5R6, S(O)R5, S(O)2R5, S(O)NR5R6, S(O)2NR5R6, NR6C(O)R5, NR6C(O)OR5, alkyls, alkenyls, alkynyls, aryls, heteroaryls, aralkyls or heteroaralkyls, all optionally substituted; Ra represents in particular halogen, hydroxyl, alkoxy, nitro; Rb represents in particular hydrogen, halogen, cyano, nitro, trifluoromethyle, -W-(C1- C3 alkyl)m- R5; R5 and R6 represent in particular alkyl, aralkyl or heteroaralkyls optionally substituted; said products being all in the form of isomers and salts, and their use as medicines.
L'invention concerne les nouveaux produits de formule (I): dans laquelle A1 et A2 représentent CH ou N; X représente CRa ou N; Y représente CRb ou N; R1, R2, R3 et R4 identiques ou différents représentent notamment hydrogène, halogène, cyano, nitro, trifluorométhyle, OR5, SR5, NR5R6, C(O)R5, C(O)OR5, C(O) NR5R6, S(O)R5, S(O)2R5, S(O)NR5R6, S(O)2NR5R6, NR6C(O)R5, NR6C(O)OR5, alkyles, alkényles, alkynyles, aryles, hétéroaryles, aralkyles ou hétéroaralkyles, tous éventuellement substitués; Ra représente notamment halogène, hydroxyle, alcoxy, nitro; Rb représente notamment hydrogène, halogène, cyano, nitro, trifluorométhyle, -W-(CI- C3alkyle)m- R5 ; R5 et R6 représente notamment alkyle, aralkyle ou hétéroaralkyles éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
Bertin Luc
Carrez Chantal
Maillet Patrick
Ruxer Jean-Marie
Thompson Fabienne
Aventis Pharma S.a.
Robic
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