Novel 3-fused pyridiniummethyl cephalosporins

Details Novel 3-fused pyridiniummethyl cephalosporins Novel 3-fused pyridiniummethyl cephalosporins

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2111459

2111459 9222556 PCTABS00018 Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed is a process for preparing the cephalosporin derivatives which comprises introducing a fused pyridiniummethyl substituent at 3-position of 7-.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamino]-3-cephem-carbo_ xylic acid derivatives. The compounds of the present invention show potent antibacterial activities and a broad spectrum against both gram-positive and gram-negative bacterial.

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