C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/18 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 9/22 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2230452
The invention relates to the discovery of a novel RNA sequence at the 3' terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3' sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full- length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication- competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
On a découvert une nouvelle séquence d'ARN au niveau de la séquence terminale 3' de l'ARN du génome du virus de l'hépatite C (VHC). L'invention concerne la séquence 3', son complément et leur utilisation pour les diagnostics fondés sur les acides nucléiques et pour la mise au point et l'évaluation de nouvelles thérapies anti-VHC. Cet élément de séquence, conservé parmi les génotypes de VHC, est probablement essentiel à la réplication du virus, et nécessaire à la construction de clones complets par ADNc de VHC capables de donner de l'ARN infectieux, un virus de descendance ou des réplicons de VHC aptes à la réplication. Ces clones fonctionnels sont des outils utiles pour l'évaluation des méthodes thérapeutiques et servent de substrats pour la mise au point de dérivés de VHC atténués ou inactivés qui permettraient éventuellement la vaccination contre le VHC.
Kolykhalov Alexander A.
Rice Charles III
Mcfadden Fincham
Washington University
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