Novel 4-[3-benzofuranyl]piperidinyl and...

Details Novel 4-[3-benzofuranyl]piperidinyl and... Novel 4-[3-benzofuranyl]piperidinyl and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2137673

The invention is concerned with novel compounds of formula (I), the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein X is oxygen or sulphur; R1 is hydrogen or halo; R2 is hydrog- en, C1-4alkyl, phenylmethyl or halophenylmethyl; Alk is C1-4alkanediyl; -Z-A- is a bivalent radical selected from the group consisting of -S-CH2-CH2, -S-CH2-CH2-CH2-, -S-CH=CH-, -CH=CH-CH=CH-, -C(=CHR3)- CH2-CH2-CH2-, -CH=CH-O-, -CHR4-CH2-CH2-, -CHR4-CH2-CH2-CH2-, -CHR4-CH2-CH2-CH2-CH2-; in said bivalent radicals one hy- drogen may be replaced by C1-4alkyl; R3 is phenyl or halophenyl; each R4 independently represents hydrogen, hydroxy, phenylmethyl or halophenylmethyl. Pharmaceutical compositions of said compounds and use as a medicine.

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