C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2619459
The present invention relates to novel 4-amino-thieno[3,2-c]pyridine-7- carboxylic acid amides of formula (I), and their pharmaceutically acceptable salts and esters which compounds of formula (I) are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions or medicaments containing these compounds, processes for making them and methods of treating cancer using these compounds.
La présente invention concerne de nouveaux amides de l~acide 4-amino-thiéno[3,2-c]pyridine-7-carboxylique répondant à la formule I, et leurs sels et esters pharmaceutiquement acceptables, lesquels composés répondant à la formule I étant des inhibiteurs sélectifs de KDR et/ou FGFR kinases. Ces composés et leurs sels pharmaceutiquement acceptables sont des agents anti-prolifératifs utiles dans le traitement ou la lutte contre des tumeurs solides, en particulier les tumeurs solides du sein, du colon, du poumon et de la prostate. En outre, la présente invention concerne des compositions pharmaceutiques ou des médicaments contenant ces composés, leurs procédés de fabrication et des procédés de traitement du cancer utilisant ces composés.
Luk Kin-Chun
Mcdermott Lee Apostle
Rossman Pamela Loreen
Wovkulich Peter Michael
Zhang Zhuming
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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