C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/82 (2006.01) A61K 31/4412 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 213/80 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2587178
The invention provides novel, substituted 4-arylamino pyridone compounds (formula (I)), pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R 1, R2, R9, R 10, R 11, R 12, R 13, R 14 and L are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
L'invention concerne des composés de 4-arylamino pyridone substitués de formule (I); des sels, des solvates et des composés de promédicaments acceptables sur le plan pharmaceutique de ceux-ci. Dans la formule (I), W, R1, R2, R9, R10, R11, R12, R13, R14 et L sont tels que définis dans la description. De tels composés sont des inhibiteurs de MEK et sont utiles dans le traitement de maladies hyperprolifératives, telles que le cancer, la resténose et des inflammations. L'invention concerne également l'utilisation de tels composés dans le traitement de maladies hyperprolifératives chez des mammifères, notamment des êtres humains, et des compositions pharmaceutiques renfermant de tels composés.
Abel Ulrich
Deppe Holger
Feurer Achim
Goutopoulos Andreas
Graedler Ulrich
Kirby Eades Gale Baker
Laboratoires Serono S.a.
Merck Serono Sa
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