Novel 4-benzimidazol-2-yl-pyridazin-3-one derivatives

Details Novel 4-benzimidazol-2-yl-pyridazin-3-one derivatives Novel 4-benzimidazol-2-yl-pyridazin-3-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2555161

The invention relates to compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

La présente invention concerne des composés représentés par la formule générale (I), dans laquelle la définition des substituants A, B, D, E, R?1 ¿et R?2¿ est détaillée dans les descriptions et, des sels de ceux-ci répondant aux normes physiologiques et, un processus de préparation de ces composés et l'utilisation de ceux-ci comme produits pharmaceutiques. Ces composés sont des inhibiteurs de kinase, en particulier des inhibiteurs de la kinase CDK2 (kinase 2 dépendant de la cycline).

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