C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/93 (2006.01) A61K 31/335 (2006.01) A61K 31/41 (2006.01) A61P 31/00 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2681379
This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1 - R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
Cette invention porte sur des composés de formule (I) : où A, B, D, E, m et R1 - R5 sont tels que décrits présentement, comme stéréoisomères individuels ou comme mélanges de stéréoisomères, ou sur des sels ou clathrates pharmaceutiquement acceptables ou des pro-médicaments de ceux-ci, lesquels composés sont utiles dans le traitement de maladies respiratoires associées aux Influenzavirus A, tels que, par exemple, H5N1 et ses mutations. L'invention porte également sur des compositions pharmaceutiques comprenant les composés de l'invention et sur des procédés de préparation des composés de l'invention.
Faulds Daryl
Guilford William J.
Kochanny Monica
Lee Wheeseong
Raduchel Bernd
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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