C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/18 (2006.01) A61K 31/405 (2006.01) A61P 43/00 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2447305
The invention concerns 5-phenyl-1H-indole derivatives of formula (I), wherein: R¿1?, R¿2?, R¿3? and R¿4? are such as defined in Claim 1, as well as their pharmaceutically acceptable salts, solvates and hydrates. The invention also concerns pharmaceutical compositions containing them, and their use for preparing medicines mediated by the activation of the CXCR receptor of interleukine-8 and chemokines of the same family.
La présente invention concerne les dérivés de 5-phényl-iH-indole de formule (I): dans laquelle R1, R2, R3 et R4 sont tels que définis à la revendication 1, ainsi que leurs sels, solvats et hydrates pharmaceutiquement acceptables. L'invention a également pour objet les compositions pharmaceutiques les contenant, ainsi que leur utilisation pour la préparation de médicaments destinés à traiter les maladies dépendantes de l'activation du récepteur CXCR2 de l'interleukine-8 et des chimiokines de la même famille.
Barth Martine
Dodey Pierre
Paquet Jean-Luc
Laboratoires Fournier Sa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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