C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/075 (2006.01) A61K 31/7048 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2446763
The invention relates to novel compounds having formula (I) in which: R¿1?, R¿?2 and R¿3? are identical or different and each represent independently: - a (C¿1?-C¿6?)alkyl group, - a pyridinyl group, or a -CH¿2?-NR¿4?R¿5? group in which R¿4? and R¿5? each represent independently a hydrogen atom, a (C¿1?-C¿4?)alkyl group or R¿4? and R¿5? form, together with the nitrogen atom to which they are linked, a pyrrolidinyl, piperidinyl, hexahydroazepinyl, morpholinyl or piperazinyl group, provided that at least one of the R¿1?, R¿2? or R¿3? substituents is different from the (C¿1?-C¿6?)alkyl group. The invention also relates to the salts, solvates and hydrates thereof, particularly those that are pharmaceutically acceptable. Said compounds are used, in particular, for treating venous circulation problems.
La présente invention concerne des nouveaux composés de formule (I): dans laquelle: R1, R2 et R3 identiques ou différents représentent, chacun indépendamment: - un groupe (C1-C6)alkyle, - un groupe pyridinyle, ou - un groupe -CH2-NR4R5 dans lequel R4 et R5 représentent chacun indépendamment un atome d'hydrogène, un groupe (C1-C4)alkyle ou bien R4 et R5 forment avec l'atome d'azote auquel ils sont liés, un groupe pyrrolidinyle, pipéridinyle, hexahydroazépinyle, morpholinyle ou pipérazinyle, à condition que l'un au moins des substituants R1, R2 ou R3 soit différent du groupe (C1- C6)alkyle,ainsi que leurs sels, solvates et hydrates, notamment pharmaceutiquement acceptables. Ces composés sont utiles notamment pour le traitement des trouble de la circulation veineuse.
Barberousse Veronique
Samreth Soth
Laboratoires Fournier Sa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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