Novel 6-amino-morphinan derivatives, method of manufacturing...

C - Chemistry – Metallurgy – 07 – D

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C07D 489/08 (2006.01) A61K 31/485 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2621817

This invention relates to a class of 6-amino-morphinan compounds of formula (I) which can be used as highly active analgesics. This invention also relates to their pharmaceutically acceptable salts and easily accessible derivatives (e.g. esters or amides of the amino acid derivatives) , to a process for their manufacture and their application in the manufacture of pharmaceutical specialities.

Cette invention concerne une classe de composés de 6-amino-morphinane représentés par la formule (I) lesquels peuvent être utilisés en tant qu'analgésiques puissants. L'invention concerne également les sels pharmaceutiquement acceptables de ces composés ainsi que des dérivés facilement accessibles (par exemple, des esters ou des amides des dérivés d'acides aminés). L'invention concerne également un procédé permettant de les fabriquer ainsi que l'utilisation de ces composés pour la fabrication de spécialités pharmaceutiques.

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