Novel 6 or 7 substituted analogues of swainsonine, processes...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2268114

The invention relates to 6 or 7 substituted swainsonine analogues. In formula (I): (a) R1, R3 and R5 are the same or different and represent hydrogen, alkyl, or aryl; (b) R2, R4 and R6 represent hydroxyl or alkoxy; and one of Y and Y'represents hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, aryl, alkoxy, or aryloxy, and the other of Y and Y' represents hydrogen, and Z and Z' represent hydrogen; or, one of Z and Z' represents alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, aryl, alkoxy, or aryloxy and the other of Z and Z' represents hydrogen, and Y and Y' represent hydrogen, and their use in stimulating the immune system, treating proliferative disorders, or microbial infections.

L'invention concerne des analogues de la swainsonine substitués en position 6 ou 7, leurs procédés de préparation et leur utilisation comme agents thérapeutiques. Elle concerne également des compositions pharmaceutiques contenant ces composés et leurs utilisation comme agents thérapeutiques.

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