Novel 6-substituted oxa- or azasteroid compound

Details Novel 6-substituted oxa- or azasteroid compound Novel 6-substituted oxa- or azasteroid compound

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2179643

A 6-substituted oxa- or azasteroid compound represented by general formula (I), having an excellent aromatase inhibitory activity, and being useful for preventing or treating diseases caused by estrogens, such as mammary cancer, uterus carcinoma, prostatic hypertrophy, and so forth. This compound has an oxygen or nitrogen atom in the steroidal D ring and the 6-position (R1) is substituted by -S-R2 (R2 representing hydrogen, lower alkyl, cyano or acyl), - O-R3 (R3 representing hydrogen, lower alkyl, or acyl), azido or amino.

Composé oxa- ou azastéroïde substitué en position 6 de formule générale (I) ayant une excellente activité d'inhibition de l'aromatase, et utile pour prévenir ou traiter des maladies causées par les oestrogènes telles que, entre autres, le cancer du sein, le cancer de l'utérus, l'adénome de la prostate. Ledit composé possède un atome d'oxygène ou d'azote dans l'anneau D stéroïde et la position 6 (R?1¿) est substituée par -S-R?2¿ (R?2¿ représentant hydrogène, alkyle inférieur, cyano ou acyle), -O-R?3¿ (R?3¿ représentant hydrogène, alkyle inférieur ou acyle), azido ou amino.

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