Novel 7-aminopyrido [2,3-d]pyrimidine derivatives

Details Novel 7-aminopyrido [2,3-d]pyrimidine derivatives Novel 7-aminopyrido [2,3-d]pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2301491

The invention provides 7-amino-1-phenylpyrido[2,3-d]pyrimidine-2,4-dione derivatives of the formula (I) or a pharmaceutically acceptable salt or hydrate thereof; Image wherein R1 is hydrogen, lower alkenyl, phenyl or optionally substituted lower alkyl which is optionally substituted with a substituent selected from oxo; lower alkoxy; phenyl which is optionally substituted with one or more lower alkyl, lower alkoxy, carboxyl, lower alkoxycarbonyl, mercapto, halogen, trifluoromethyl and/or nitro; naphthyl; furyl; isoxazolyl which is optionally substituted with one or more lower alkyl; pyridyl which is optionally substituted with one or more lower alkyl and/or halogen; thienyl which is optionally substituted with halogen; and 1,3-dioxolanyl; and R2, R3 and R4 each independently is hydrogen, halogen, lower alkoxy, benzyloxy, carboxyl or lower alkoxycarbonyl, which is useful for a therapeutic agent for bronchial asthma by exhibiting excellent bronchial dilating action as well as high safety and favorable behavior in vivo.

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