Novel 8-substituted-2-aminotetralines

Details Novel 8-substituted-2-aminotetralines Novel 8-substituted-2-aminotetralines

C - Chemistry, Metallurgy

07

C

C07C 225/20 (2006.01) A61K 31/135 (2006.01) C07C 211/42 (2006.01) C07C 229/50 (2006.01) C07C 309/65 (2006.01) C07D 307/52 (2006.01) C07D 307/81 (2006.01)

Patent

CA 2032498

A compound of formula (I), where Z is hydrogen or halogen, Q is COR1 or 5- or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, O or S and may be substituted or fused wherein R is hydrogen or C1-methyl (cis- configuration) , R1 is C1-C6 alkyl or an aromatic ring which may contain heteroatoms selected from O and S and may be substituted or fused to an optionally substituted benzene ring, R2 is hydrogen or C1-C6 alkyl and R3 may be different groups defined in claim 1, and enantiomers/salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds.

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