C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) A61K 31/353 (2006.01) C07D 335/06 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2173257
Compounds of general formula (I), wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer and in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.
Sont décrits des composés de formule générale (I) où R¿1? est n-propyle ou cyclobutyle; R¿2? est isopropyle, butyle tertiaire, cyclobutyle, cyclopentyle ou cyclohéxyle; R¿3? est hydrogène; R¿4? est hydrogène ou méthyle; se présentant sous forme de (R)-énantiomères et de bases libres ou bien de sels pharmaceutiquement acceptables; un procédé pour leur préparation, une composition pharmaceutique, leur utilisation et un procédé de traitement de troubles du système nerveux central.
Evenden John Leslie
Hammarberg Eva Maria
Hansson Hans Sverker
Hellberg Sven Erik
Johansson Lars George
Astra Aktiebolag
Fetherstonhaugh & Co.
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