Novel abc transporter and uses thereof

Details Novel abc transporter and uses thereof Novel abc transporter and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2383074

The invention provides isolated nucleic acid molecules, designated ABCB12 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCB12 transported nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ABCB12 transported gene has been introduced or disrupted. The invention still further provides isolated ABCB12 transporter proteins, fusion proteins, antigenic peptides, anti-ABCB12 transporter antibodies, and screening assays for ABCB12 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acide nucléique isolées désignées molécules d'acide nucléique du transporteur ABCB12, codant de nouveaux membres de la famille du transporteur ABC. Elle concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinants contenant des molécules d'acide nucléique du transporteur ABCB12, des cellules hôtes dans lesquelles on a introduit ces vecteurs d'expression et des animaux transgéniques non humains dans lesquels on a introduit ou interrompu le gène du transporteur ABCB12. Elle concerne encore des protéines de transport ABCB12 isolées, des protéines de fusion, des peptides antigéniques, des anticorps anti-transporteur ABCB12 et des méthodes de criblage servant à rechercher des modulateurs du transporteur ABCB12. Elle concerne, de plus, des procédés diagnostiques et thérapeutiques mettant en application des compositions décrites par l'invention.

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