Novel acetyl-coa carboxylase (acc) inhibitors and their use...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 417/04 (2006.01) A61K 31/427 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2641734

The present invention relates to compounds of formula (I), wherein R1 is selected from the group consisting of hydrogen, cycloalkyl, alkyl and haloalkyl; Y is selected from the group consisting of -(CR4aR-4b)m-, -C(O)-, - O-, -N(H)-, -N(alkyl)- and -S-; wherein m is 1, 2 or 3; Ar3 is phenyl or monocyclic heteroaryl; wherein Ar3 is substituted with 1, 2 or 3 or 4 substituents. Ar1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl; Ar2 is a monocyclic five membered heteroaryl, wherein each Ar2 is independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of alkyl, alkenyl, halogen, -CN, -NO2, hydroxy, alkoxy, -NH2, -N(H)(alkyl), - N(alkyl)2. -C(O)OH, -C(O)Oalkyl, -C(O)H, -C(O)alkyl, and haloalkyl; Z is selected from the group consisting of -OR9a, -alkylenyl-OR9a, -NR6R99b; and - alkylenyl-NR6R9b; which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type U diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

La présente invention concerne des composés de formule (I), qui inhibent l'acétyl-CoA carboxylase (ACC) et qui sont utiles pour la prévention ou le traitement du syndrome métabolique, du diabète de type II, de l'obésité, de l'athérosclérose et des maladies cardiovasculaires chez l'homme.

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