C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/08 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2581402
A sugar uptake activator containing a substance having a PGC-1.beta. action as an active ingredient and a method for screening a sugar uptake activator comprising the steps of bringing a test substance into contact with a PGC- 1.beta. gene promoter and analyzing the activity of the PGC-1.beta. gene promoter are disclosed. The sugar uptake activator is a novel therapeutic agent for diabetes that facilitates sugar uptake in a muscular tissue in a hyperglycemic condition regardless of blood insulin level.
La présente invention concerne un activateur de l'assimilation du sucre contenant, en tant que principe actif, une substance dotée d'une action PGC-1ß, ainsi qu'un procédé de criblage d'un activateur de l'assimilation du sucre comprenant les étapes consistant à mettre en contact une substance expérimentale avec un promoteur du gène PGC-1ß et à analyser l'activité du promoteur du gène PGC-1ß. L'activateur de l'assimilation du sucre est un nouvel agent thérapeutique pour le diabète qui facilite l'assimilation du sucre dans les tissus musculaires dans un état hyperglycémique, quel que soit le taux d'insuline.
Goto Masahide
Shimokawa Teruhiko
Astellas Pharma Inc.
Dennison Associates
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