Novel active ingredient in cicatrization and use thereof

Details Novel active ingredient in cicatrization and use thereof Novel active ingredient in cicatrization and use thereof

A - Human Necessities

61

K

A61K 31/7016 (2006.01) A61K 31/795 (2006.01) A61L 15/44 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2687730

The present invention relates to the use of a known compound as an agent for promoting and/or accelerating fibroblast proliferation and/or differentiation and, consequently, cicatrization. This compound is a copolymer of a 2-methyl-2-[(1-oxo-2-propenyl)amino]-1- propanesulphonic acid salt and of propenoic acid 2-hydroxyethyl ester. It may be used alone or in combination with other active substances for inducing or accelerating cicatrization. This compound, alone or in combination with another active substance, may be administered directly on the wound and the surrounding area or the mucous membranes, by topical application. It may also be used ex vivo, in particular for generating cells for skin grafts.

La présente invention concerne l'utilisation, comme agent favorisant et/ou accélérant la prolifération et/ou la différenciation des fibroblastes et par conséquent la cicatrisation d'un composé connu. Ce composé est un copolymère d'un sel de l'acide 2-méthyl-2-[(1-oxo-2-propènyl)amino]-1- propanesulfonique et de l'ester 2-hydroxyéthyle de l'acide propénoïque. Il peut être utilisé seul ou en combinaison avec d'autres substances actives permettant d'induire ou d'accélérer la cicatrisation. Ce composé, seul ou en combinaison avec une autre substance active peut être administré directement au niveau de la plaie et de son environnement ou des muqueuses par voie topique. Il peut également être utilisé ex vivo, notamment pour la génération de cellules pour des greffes de peau.

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