Novel adjuvant compositions and vaccine formulations...

Details Novel adjuvant compositions and vaccine formulations... Novel adjuvant compositions and vaccine formulations...

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2219904

An adjuvant for administration to a host animal to enhance immune response, comprising a polysaccharide-phospholipid conjugate, whose polysaccharide moiety may for example comprise a modified glucan, chitosan, or alginate polysaccharide, conjugated to a phospholipid. The adjuvant may be suitably formulated with an antigen to provide a therapeutic vaccine for a variety of disease states and/or physiological conditions.

L'invention concerne un adjuvant destiné à être administré à un animal hôte pour renforcer la réponse immune, comprenant un conjugué de polysaccharide-phospholipide, dont la fraction polysaccharide peut, par exemple, comprendre une glucane, un chitosane ou un polysaccharide alginate modifié, conjugué avec un phospholipide. L'adjuvant peut avantageusement être formulé avec un antigène pour produire un vaccin thérapeutique destiné à une variété d'états pathologiques et/ou à une variété de conditions physiologiques.

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