C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 251/70 (2006.01) B01J 20/32 (2006.01) C07D 239/26 (2006.01) C07D 251/50 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 7/10 (2006.01) C07K 1/22 (2006.01) C07K 14/61 (2006.01) C07K 14/62 (2006.01) C07K 16/00 (2006.01) C08B 15/06 (2006.01) C08B 37/12 (2006.01) C12N 9/64 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2232626
The present invention relates to novel affinity ligand-matrix conjugates comprising a ligand with general formula (a), which ligand is attached to a support matrix in position (A), optionally through a spacer arm interposed between the matrix and ligand. The invention furthermore relates to these novel affinity ligand-matrix conjugates and the preparation and use thereof in the purification of proteinaceous materials such as e.g. immunoglobulins, insulins, Factor VII, or human Growth Hormone or analogues, derivates and fragments thereof and precursors.
Cette invention a trait à de nouveaux conjugués ligand à affinité-matrice comportant un ligand de la formule générale (a). Ce ligand est rattaché à une matrice de support en position A, éventuellement par le biais d'un bras d'espacement s'interposant entre la matrice et le ligand. Cette invention porte, en outre, sur ces nouveaux conjugués ligand à affinité-matrice, sur leur préparation et leur utilisation dans le cadre de la purification de matières protéiniques telles que des immunoglobulines, des insulines, le facteur VII ou l'hormone de croissance humaine, par exemple, ou bien de leurs analogues, dérivés et fragments et précurseurs.
Burton Steven J.
Li Rongxiu
Lowe Christopher R.
Pearson James C.
Sproule Kenneth
Affinity Chromatography Ltd.
Mccarthy Tetrault Llp
Novo Nordisk A/s
Prometic Biosciences Ltd
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